The driving time from St. Louis to Joplin via U.S. Route 66 is 13 hours 17 minutes by road. You can also find other options to travel from St. Louis to Joplin via U.S. Route 66 like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from St. Louis to Joplin via U.S. Route 66!