To find the driving direction from San Francisco to San Diego via Santa Cruz, San Luis Obispo, Santa Barbara, Anaheim which is 889 by road, click on Show Directions after entering start and end locations in the calculator control. It takes around 553 to reach San Francisco to San Diego via Santa Cruz, San Luis Obispo, Santa Barbara, Anaheim. Tired of travelling by road? You can just fly from San Francisco to San Diego via Santa Cruz, San Luis Obispo, Santa Barbara, Anaheim. Check the
Flight Time from San Francisco to San Diego via Santa Cruz, San Luis Obispo, Santa Barbara, Anaheim before travelling.