The driving time from Tupelo to Pensacola via Interstate 20, U.S. Route 231, U.S. Route 166 is 101 hours 18 minutes by road. You can also find other options to travel from Tupelo to Pensacola via Interstate 20, U.S. Route 231, U.S. Route 166 like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Tupelo to Pensacola via Interstate 20, U.S. Route 231, U.S. Route 166!