The driving time from San Luis Obispo to San Francisco via Highway 1, Highway 1 is 4 hours 49 minutes by road. You can also find other options to travel from San Luis Obispo to San Francisco via Highway 1, Highway 1 like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from San Luis Obispo to San Francisco via Highway 1, Highway 1!