The driving time from San Francisco to San Luis Obispo via Highway 1, Santa Cruz, Monterey is 38 hours 37 minutes by road. You can also find other options to travel from San Francisco to San Luis Obispo via Highway 1, Santa Cruz, Monterey like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from San Francisco to San Luis Obispo via Highway 1, Santa Cruz, Monterey!