The driving time from Napa to Lake Tahoe via San Luis Obispo, San Francisco is 11 hours 47 minutes by road. You can also find other options to travel from Napa to Lake Tahoe via San Luis Obispo, San Francisco like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Napa to Lake Tahoe via San Luis Obispo, San Francisco!