The driving time from Houston to Key west FL via New Orleans, Panama City Beach, Orlando, Port St. Lucie is 22 hours 59 minutes by road. You can also find other options to travel from Houston to Key west FL via New Orleans, Panama City Beach, Orlando, Port St. Lucie like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Houston to Key west FL via New Orleans, Panama City Beach, Orlando, Port St. Lucie!