The distance between Santa Clarita to San Luis Obispo via Hwy 101 is 681 Mi by road. You can also find the distance from Santa Clarita to San Luis Obispo via Hwy 101 using other travel options like bus, subway, tram, train and rail. Apart from the trip distance, refer
Directions from Santa Clarita to San Luis Obispo via Hwy 101 for road driving directions!