The distance between Oklahoma City to Amarillo via U.S. Rt. 66 is 756 Mi by road. You can also find the distance from Oklahoma City to Amarillo via U.S. Rt. 66 using other travel options like bus, subway, tram, train and rail. Apart from the trip distance, refer
Directions from Oklahoma City to Amarillo via U.S. Rt. 66 for road driving directions!