The distance between Napa to San Luis Obispo via 101 Pacific Coast Hwy is 946 Mi by road. You can also find the distance from Napa to San Luis Obispo via 101 Pacific Coast Hwy using other travel options like bus, subway, tram, train and rail. Apart from the trip distance, refer
Directions from Napa to San Luis Obispo via 101 Pacific Coast Hwy for road driving directions!