The driving time from Portofino to Rome via Siena, Florence, Assisi is 8 hours 25 minutes by road. You can also find other options to travel from Portofino to Rome via Siena, Florence, Assisi like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Portofino to Rome via Siena, Florence, Assisi!