The driving time from Amarillo to Holbrook via U.S. Rt. 66 is 18 hours 56 minutes by road. You can also find other options to travel from Amarillo to Holbrook via U.S. Rt. 66 like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Amarillo to Holbrook via U.S. Rt. 66!