The driving time from Florence to Rome via Città di Castello, Assisi, Orvieto is 5 hours 23 minutes by road. You can also find other options to travel from Florence to Rome via Città di Castello, Assisi, Orvieto like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Florence to Rome via Città di Castello, Assisi, Orvieto!