To find the driving direction from Rome to Florence via Assisi, Tuscany, Siena which is 514 by road, click on Show Directions after entering start and end locations in the calculator control. It takes around 401 to reach Rome to Florence via Assisi, Tuscany, Siena. Tired of travelling by road? You can just fly from Rome to Florence via Assisi, Tuscany, Siena. Check the
Flight Time from Rome to Florence via Assisi, Tuscany, Siena before travelling.