The driving time from Sault Ste. Marie to Niagara Falls via Thru USA is 21 hours 7 minutes by road. You can also find other options to travel from Sault Ste. Marie to Niagara Falls via Thru USA like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Sault Ste. Marie to Niagara Falls via Thru USA !