To find the driving direction from Los Angeles to San Luis Obispo via pacific coast highway, Lompoc, Guadalupe which is 381 by road, click on Show Directions after entering start and end locations in the calculator control. It takes around 255 to reach Los Angeles to San Luis Obispo via pacific coast highway, Lompoc, Guadalupe. Tired of travelling by road? You can just fly from Los Angeles to San Luis Obispo via pacific coast highway, Lompoc, Guadalupe. Check the
Flight Time from Los Angeles to San Luis Obispo via pacific coast highway, Lompoc, Guadalupe before travelling.