The driving time from Rome to Pisa via SR2, 53045 Montepulciano SI, 53100 Siena is 6 hours 14 minutes by road. You can also find other options to travel from Rome to Pisa via SR2, 53045 Montepulciano SI, 53100 Siena like bus, subway, tram, train and rail. To know the travel distances while planning a journey, find the
Distance from Rome to Pisa via SR2, 53045 Montepulciano SI, 53100 Siena!