The distance between Rome to Florence via Assisi, Perugia, Firenze is 355 Km by road. You can also find the distance from Rome to Florence via Assisi, Perugia, Firenze using other travel options like bus, subway, tram, train and rail. Apart from the trip distance, refer
Directions from Rome to Florence via Assisi, Perugia, Firenze for road driving directions!