The distance between Florence to Rome via Città di Castello, Assisi, Orvieto is 399 Km by road. You can also find the distance from Florence to Rome via Città di Castello, Assisi, Orvieto using other travel options like bus, subway, tram, train and rail. Apart from the trip distance, refer
Directions from Florence to Rome via Città di Castello, Assisi, Orvieto for road driving directions!